Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
Abstract Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades.At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clinical efficacy in treating C.difficile infection (CDI).Most metronidazole-resistant C.diffici